Consume the contents of one packet with a meal, one to two times daily, or as directed by your healthcare practitioner.

Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.

Wheat, gluten, corn protein, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

Keep closed in a cool, dry place out of reach of children.

for Ossopan 1100™ with vitamin D3:HPMC (capsule), vegetable stearic acid, vegetable magnesium stearate, medium-chain triglycerides, and silica. for ch-OSA®: Microcrystalline cellulose, HPMC (capsule), and purified water.

• Provide a Multifaceted Approach to Bone Maintenance and Strength*
• Provide Foundational Support with Choline-Stabilized Orthosilicic Acid (ch-OSA®)*
• Support Bone Collagen Formation, Bone Mineral Density, and Bone Calcium Binding Sites*
• Provide a Complementary Combination of Micronutrients*

Bone health is dependent on a constant supply of micronutrients for maintenance and repair. Instead of adopting a single-nutrient, unbalanced approach to supplementation, True Balance utilizes an array of complementary, well-researched nutrients in its Bone Complex formulas to build and maintain bone over time.*

Silicon as Choline-Stabilized Orthosilicic Acid (ch-OSA®) Bone Complex formulas feature ch-OSA, a patented, stabilized, readily absorbed, bioactive form of silicon called orthosilicic acid. Decades of research suggest that there is a strong, positive association between dietary silicon and bone mineral density (BMD).[1] The mechanisms of action appear to be silicon’s support of collagen synthesis and stabilization, extracellular matrix mineralization, and connective tissue integrity.[2,3] In cell-line studies, orthosilicic acid has been found to stimulate type I collagen synthesis.[4] Type I collagen is a dense, heavily cross-linked protein that creates an extremely high tensile strength[5] and contributes to bone strength and flexibility. These strong collagen strands are believed to create core-post “binding sites” for calcium and other bone minerals.[6-8] A 12-month, randomized, double-blind, placebo-controlled (RDBPC) trial suggested that supplementing with ch-OSA conferred an additional benefit to a calcium/vitamin D regimen by improving bone formation markers and femoral neck T-scores.*

Vitamin D3 Cholecalciferol (vitamin D3) is the form of vitamin D that is endogenously synthesized in skin during exposure to sunlight. Unfortunately, several factors can limit this production including smog, sunblock, and geographic location. For many individuals, exogenous supplementation may be beneficial. Vitamin D plays a role in bone metabolism, BMD, and calcium/phosphorus status; researchers suggest that vitamin D supplementation may decrease bone turnover and increase BMD.[10] Several randomized placebo-controlled trials with vitamin D and calcium showed significant improvement in maintenance of bone integrity.[10] One randomized, populationbased, three-year trial indicated that supplementation with vitamin D (800 IU/d) and calcium (1000 mg/d) had a positive and statistically significant impact on total body bone integrity.[11] A pooled analysis evaluating 11 RDBPC trials concluded that vitamin D supplementation (>800 IU daily) was favorable in maintaining hip and nonvertebral bone integrity in those aged 65 and older.[12] The vitamin D3 in Bone Complex Vegan is from an edible lichen source and is vegan-suitable.*

Calcium as Microcrystalline Hydroxyapatite Concentrate (MCHC) Bone Complex and Bone Complex MK-7 contain Ossopan MCHC, a premium, standardized bone extract from New Zealand bovine. This hydroxyapatite matrix comprises calcium, phosphorus, magnesium, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements. Hydroxyapatite is essentially a mineralized matrix that promotes resistance to compression and can be compared to reinforced concrete.[5] Decades of scientific studies suggest that Ossopan supplementation fundamentally supports BMD and bone health.[13-16] A meta-analysis of six controlled studies suggested that hydroxyapatite was significantly more effective than calcium carbonate in supporting bone structure and BMD.*[

Menaquinone-7 (MK-7) Bone Complex MK-7 and Bone Complex Vegan contain MK-7, a bioactive, bioavailable form of vitamin K.[18] Vitamin K plays an active role in bone metabolism, calcium utilization, and activation of osteocalcin (the protein needed to bind calcium to the mineral matrix in bone). Vitamin K supports bone integrity by moderating the synthesis of prostaglandin E2 and interleukin-6 by osteoclasts.[19,20]. A three-year study utilizing 180 μg/d of MK-7 concluded that MK-7 significantly improved vitamin K status, supported bone mineral content and BMD, and favorably supported bone strength and integrity in healthy postmenopausal women.*

Olive Leaf Extract Bonolive®, found in Bone Complex Vegan, is a pharmaceutical-grade olive leaf extract that features a unique polyphenol complex. Stem cell research suggested that olive polyphenols are associated with increased osteoblast differentiation, increased extracellular matrix mineralization, and bone maintenance.[22] Research on cultured cells and animals suggested that olive polyphenols exert protective effects on the formation and maintenance of bone.[23] A randomized, double-blind, placebocontrolled clinical study provided strong support for Bonolive supplementation. Results revealed that 250 mg/d of Bonolive, along with routine calcium supplementation, promoted a statistically significant improvement (32% increase) in levels of the bone formation marker osteocalcin over a 12-month period. Furthermore, DEXA scan results suggested that Bonolive supplementation positively supported BMD at the lumbar spine and the femur neck compared to placebo.*